Arjun Rustagi, MD, PhD

Arjun Rustagi
Assistant Professor
Medicine

Dr. Arjun Rustagi is dedicated to understanding the early immune responses to infections, and the methods pathogens use to persist despite these responses, in order to inform new prevention and treatment strategies. His research has focused on viral pathogenesis and immunity. He set up the respiratory viral biosafety level 3 (BSL3) program at Stanford in early 2020 in order to study SARS-CoV-2, contributing to several projects in SARS-CoV-2 virology including a study of intact in vitro lung tissue infection. He also protocoled the first peripheral immune profiling study of severe COVID-19. His ongoing interest is in the full spectrum of in vitro respiratory pathogen models, particularly those that recapitulate lung epithelium and mucosal immunity.

Publications

First, do NOHARM: towards clinically safe large language models.

ArXiv

Wu D, Haredasht FN, Maharaj SK, Jain P, Tran J, Gwiazdon M, Rustagi A, Jindal J, Koshy JM, Kadiyala V, Agarwal A, Tappuni B, French B, Jesudasen S, Cosgriff CV, Chakraborty R, Caldwell J, Ziolkowski S, Iberri DJ, Diep R, Dalal RS, Newman KL, Galetta K, Pallais JC, Wei N, Buchheit KM, Hong DI, Lee EY, Shih A, Pahalyants V, Kaplan TB, Ravi V, Khemani S, Liang AS, Shirvani D, Patil A, Marshall N, Chopra K, Koh J, Badhwar A, McCoy LG, Wu DJH, Weng Y, Ranji S, Schulman K, Shah NH, Hom J, Milstein A, Rodman A, Chen JH, Goh E

Viral immunity: Basic mechanisms and therapeutic applications-a Keystone Symposia report.

Annals of the New York Academy of Sciences

Cable J, Balachandran S, Daley-Bauer LP, Rustagi A, Antony F, Frere JJ, Strampe J, Kedzierska K, Cannon JL, McGargill MA, Weiskopf D, Mettelman RC, Niessl J, Thomas PG, Briney B, Valkenburg SA, Bloom JD, Bjorkman PJ, Iketani S, Rappazzo CG, Crooks CM, Crofts KF, Pöhlmann S, Krammer F, Sant AJ, Nabel GJ, Schultz-Cherry S

An intranasal ASO therapeutic targeting SARS-CoV-2.

Nature communications

Zhu C, Lee JY, Woo JZ, Xu L, Wrynla XH, Yamashiro LH, Ji F, Biering SB, Van Dis E, Gonzalez F, Fox D, Wehri E, Rustagi A, Pinsky BA, Schaletzky J, Blish CA, Chiu C, Harris E, Sadreyev RI, Stanley S, Kauppinen S, Rouskin S, Näär AM

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.

Nature genetics

Biering SB, Sarnik SA, Wang E, Zengel JR, Leist SR, Schäfer A, Sathyan V, Hawkins P, Okuda K, Tau C, Jangid AR, Duffy CV, Wei J, Gilmore RC, Alfajaro MM, Strine MS, Wrynla XH, Van Dis E, Catamura C, Yamashiro LH, Belk JA, Begeman A, Stark JC, Shon DJ, Fox DM, Ezzatpour S, Huang E, Olegario N, Rustagi A, Volmer AS, Livraghi-Butrico A, Wehri E, Behringer RR, Cheon DJ, Schaletzky J, Aguilar HC, Puschnik AS, Button B, Pinsky BA, Blish CA, Baric RS, O'Neal WK, Bertozzi CR, Wilen CB, Boucher RC, Carette JE, Stanley SA, Harris E, Konermann S, Hsu PD

Anti-nucleocapsid antibody levels and pulmonary comorbid conditions are linked to post-COVID-19 syndrome.

JCI insight

Jia X, Cao S, Lee AS, Manohar M, Sindher SB, Ahuja N, Artandi M, Blish CA, Blomkalns AL, Chang I, Collins WJ, Desai M, Din HN, Do E, Fernandes A, Geng LN, Rosenberg-Hasson Y, Mahoney MR, Glascock AL, Chan LY, Fong SY, CLIAHUB Consortium, Chan Zuckerberg Biohub, Phelps M, Raeber O, Stanford COVID-19 Biobank Study Group, Purington N, Röltgen K, Rogers AJ, Snow T, Wang TT, Solis D, Vaughan L, Verghese M, Maecker H, Wittman R, Puri R, Kistler A, Yang S, Boyd SD, Pinsky BA, Chinthrajah S, Nadeau KC

Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.

Nature

Salahudeen AA, Choi SS, Rustagi A, Zhu J, van Unen V, de la O SM, Flynn RA, Margalef-Català M, Santos AJM, Ju J, Batish A, Usui T, Zheng GXY, Edwards CE, Wagar LE, Luca V, Anchang B, Nagendran M, Nguyen K, Hart DJ, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Harbury PB, Glenn JS, Garcia KC, Davis MM, Baric RS, Sabatti C, Amieva MR, Blish CA, Desai TJ, Kuo CJ